Background: Scar formation is a natural part of the wound healing process. The aim of this study was to observe the therapeutic effect of MEBO Scar ointment in the prevention and treatment of incisional scars. Methods: MEBO Scar ointment was applied 3 times daily after surgical stitches were removed in the test group. Warm saline was used in the control group. Clinical efficacy was based on scar quality assessment measuring – itching relief, skin texture, dystrophy and color. The wound was assessed at pre-determined intervals over 120 days post-surgery for therapeutic effectiveness of the ointment. Results: A total of 90 patients, male and female, undergoing elective surgery between February and December, 2013, with mean age of 30 years were included in this study. At 120 days, MEBO Scar was found to be highly effective (scar disappearance, no itching with soft scar, skin colour close to normal tissue) in majority patients (75%); and the overall scar quality was found to be significantly better (p<0.001) for all parameters. Conclusion: When initiated early, standard use of MEBO Scar Ointment for adequate period of time sufficiently softens the scars to prevent proliferation and appearance disturbances, resulting in a cosmetically acceptable scar. Therefore, it may be recommended for the prevention and treatment of scars postsurgery.