Burn injuries are considered one of the major sources of trauma that might lead to substantial morbidity and mortality. Severe burns cause multiple organ dysfunction and even sometimes organ failure, leading to debility and subsequent scarring that affects the quality of life and mental health. Consequently, this study is designed to compare the outcomes of two burn treatment modalities in patients suffering from burn injuries who were admitted to the Burn Unit / AL-Hussein Teaching Hospital / Samawa / Al-Muthanna Governorate. A clinical study was established during the period from December 2018 to January 2022 60 patients of both sexes suffered from different burn injuries. All patients are treated with Moist Exposed Burn Ointment -MEBO- or with covered classic methods using silver sulphadiazine cream dressings. Follow-up of treated patients is done to evaluate the treatment outcome. Our study included 44 burned and 16 scalded cases of different age groups, with second and third burn degrees extending on different body surface areas ranging from 30-60% in males and 30-70% in females.  Of 60 patients, 40 females (67%) were between 10 and 40 years old, and 20 males (33%) were between 3 and 36 years old. The mortality percentages were 7 (23.3%) and 2 (6.6 %) cases out of a total of 60 patients for the conventional method and MEBO-treated group, respectively. Sepsis was observed in most dead cases, manifested by foul-smelling wound discharge and necrotic non-viable wound tissues, in addition to pneumonia and bronchitis. Pseudomonas sp, Klebsiella sp, and Proteus sp were isolated from these cases by culture and sensitivity tests.  In conclusion, this study showed that the MEBO cream application in treating burned injuries revealed dramatic curative hopeful results with less liability for infective and septic complications compared with the conventional method, represented by the Sulphadiazine cream application. The authors recommend using treatment in burn units instead of using the routine old conventional method to avoid the expected morbidity and mortality and gain acceptable cosmetic results.