Scar Formation, Healing Stages, and Advanced Treatment Strategies – Review

Do, Monika Kienanh; Van, Marcin Mikusek-Pham; Zaliwska, Dominika; Kraszkiewicz, Adrianna; Paduszyńska, Natalia; Gonciarz, Marta Justyna; Adamiec, Dominika Karolina; D?browska, Anna; Kamińska, Monika Anna; Czach, Magdalena
Warsaw Medical University, Warsaw, Poland; University Clinical Center Medical University of Warsaw, 02-097 Warsaw, Poland; University Clinical Hospital in Poznań, Przybyszewskiego 49, 60-355 Poznań, Poland; Dr Anna Gostynska Wolski Hospital, Independent Public Health Care Institution, Marcina Kasprzaka 17, 01-211 Warsaw, Poland; Independent Public Clinical Hospital Witolda Or?owskiego, Czerniakowska 231, 00-416 Warsaw, Poland; LUX MED, Post?pu 21C, 02-676 Warsaw, Poland
2024
2450-3118
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摘要

Introduction and Aim of the Study: Scarring is a major concern in clinical dermatology, affecting individuals' quality of life due to both physical and psychological impacts. This review aims to explore the pathophysiology of various scar types—hypertrophic, keloid, and atrophic—and evaluate the effectiveness of current and emerging treatments to inform better clinical practices and therapeutic strategies. Description of the State of Knowledge: Scar formation involves complex biological processes: inflammation, proliferation, and remodeling. The nature of the scar varies with the underlying cause and biological response, influenced by genetic factors, skin tension, and environmental elements such as UV exposure. Recent advances in treatments range from surgical techniques to laser therapy and biological agents like cytokines. Conclusion: The studies reviewed underscore the complexity of scar management, influenced by diverse genetic, biological, and environmental factors. No single treatment is universally effective, but a combination of preventative and therapeutic strategies shows the best promise.

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