摘要:目的:探讨烧伤再生疗法(BRT)和湿润烧伤膏(MEBO)治疗烧伤的临床效果。方法:该试验为前瞻性、单一中心临床研究,研究对象为2009年9月和2010年3月间筛选出的10名年龄在3个月至75岁之间的浅Ⅱ度~Ⅲ度烧伤患者,全程采用BRT和MEBO治疗,观察记录创面75%愈合时间、创面100%愈合时间、创面感染率、疼痛指数、平均住院时间、过敏反应率,并拍摄照片进行治疗前后的对比观察。结果:创面75%和100%愈合的平均时间分别为27.3天和59.0天;换药时的平均疼痛指数为4;住院时间最短9天,最长151天,平均住院时间为57.1天;细菌感染率为10%;没有发现过敏反应。结论:在本研究中,有些创面本是需要接受植皮手术的,但是经MEBO继续治疗4周~6周后能够成功实现上皮化再生愈合。因此,MEBO治疗烧伤的有效性毋庸置疑。
摘要:Objective: From molecular, cell and systemic clinical treatment three levels, this report revealed the mechanism of wound healing, the basic theory and the importance of clinical practice for the Burn Regenerative Therapy with MEBT/MEBO (BRT & MEBT/MEBO).Method: This report analyzed the importance and clinical curative effect for standardized appliance of BRT & MEBT/MEBO from two key points: 1) Liquefaction of necrotic tissue from burn wound; 2) Skin regenerationin situ. Result: There are three necessary conditions for skin physiologically repair and regeneration of burn wound: 1) The formation of moist physiological environment on burn wound; 2) The material foundation of life regenerative substances and histology for keratin-19 stem cells' regenerationin situ; 3) Standardized procedures and appliance of BRT & MEBT/MEBO, which is the guarantee of burn wound healing physiologically. Conclusion: The theory of “Potential Regenerative Cell" and the technique of “Stem cellin situregeneration" are ...