摘要：Soon-Ye Noh, R.N., Ae-Sim Kim, R.N., Hyeon-Seon Sin, R.N., Do-Hern Kim, M.D. Jun Hur, M.D.and Wook Chun, M.D.. J Korean Burn Soc 2003;6:147-52. https://doi.org/

摘要：Background:? This study aimed to investigate the efficacy and safety of CO2 fractional laser combined with Mebo burn ointment in treating facial postoperative scars. Methods:? Sixty patients with facial postoperative scars in the department of plastic surgery of Sun Yat-sen Memorial Hospital from January 2020 to June 2022 were divided into a control group (30 cases) and a study group (30 cases). Both groups received CO2 fractional laser treatment, but the study group also received Mebo burn ointment application. Results:? The study found that both methods resulted in a significant decrease in Sawada score and a significant increase in Investigator Global Assessment score after treatment (P < 0.05), with the study group showing a more significant improvement and higher patient satisfaction (P < 0.05). All patients experienced varying degrees of bleeding, swelling, and erythema immediately after treatment, with two cases of pigmentation and two cases of persistent erythema in the control group, and one case of pigmentation and one case of persistent erythema in the study group. Adverse reactions were minimal, with the study group showing better tolerance. Conclusions:? The study suggests that CO2 fractional laser combined with Mebo burn ointment is an effective and safe treatment for facial postoperative scars.

摘要：Background and objective: Vitamin K is a fat-soluble vitamin that plays an important role in the coagulation pathways of living organisms. A popular application of vitamin K has been used to help in the extravascular removal of blood from the skin. The aim of the present study was to test the wound healing effect of vitamin K and some common wound dressing agents available in Erbil city clinical settings such; the moist exposed burn ointment (MEBO) and the Cica silver spray to test their combination with vitamin K injections. Methods: Six groups of albino rats were used (6 rats in each group). Group M received Mebo ointment, Group Creceived Cica silver spray, Group K received Vitamin K injection, Group MK received Mebo ointment+vitamin K injection.Group CK received Cica silver spray +vitamin K Group, and Group N received no- treatment. The duration of the experiments was as 7, 14, and 21 days post wound surgery.The percentage of wound contraction was measured, and the blood serum was collected to test the level of transforming growth factor β (TGFβ) and platelet-derived growth factor (PDGF). Results: Data presented in our study showed that the best wound contraction percentage(99%) was obtained by the MK treated rats compared to the control group. Similar results were obtained fromTGFβ and PDGF data in which MK group showed a significant increase in the levels of these growth factors. Conclusion: The wound healing process is supposed to be due to an increase of TGFβ, PDGF, and enhanced fibroblast proliferation and neovascularization of tissues.

摘要：Improved healing of full- and partial-thickness cutaneous wounds in wet and moist environments is due primarily to retention of biological fluids over the wound preventing desiccation of denuded dermis or deeper tissues. This also allows faster and unimpeded migration of keratinocytes over the wound surface and enables the naturally occurring cytokines and growth factors to exert their beneficial effect on wound contracture and reepithelialization. Despite all these documented benefits creating and maintaining a sealed moist environment over large surface areas such as large skin graft donor sites or extensive burns is technically difficult if not impossible. The preliminary investigation carried out between 1999 and 2000 studied the healing of a split-thickness skin graft (STSG) following application of moist exposed burn ointment (MEBO). This compound provides a moist environment without the need of an overlying occlusive dressing, and compares favorably with Sofra-Tulle semi-open dressing. Healing of STSG donor sites was then evaluated from January to September 2001 in a prospective study comparing the effect of Tegaderm, a semipermeable membrane occlusive dressing, and MEBO, two different types of moist dressings. Wound healing was evaluated by measuring transepidermal water loss (TEWL), and scar quality was assessed by two independent observers using a visual analogue scale. Faster healing was observed clinically with MEBO application. Physiological healing as determined by TEWL measurements occurred at an extremely significant earlier stage for MEBO, and this was associated with better scar quality demonstrating a positive relationship between function and cosmetic appearance. Moreover, simple ointment application was definitely more practical than application of the occlusive self-adhesive membrane.