摘要：Method: Consecutive patients (n=105) with CPUs (n=218) treated at three different hospitals were randomized to receive Moist Exposed Burn Ointment (MEBO) dressings (Regenerative group, n=55 with 115 ulcers) or wet-to-moist saline dressings (Control group, n=50 with 103 ulcers). Data collected prospectively included demographics, clinical, biochemical and ulcer features. Ulcer surface area (SA) and healing index (HI) were calculated and compared at twoweek intervals for 12 weeks. Results: Sixty-one patients (58.1%) were male and 44 (41.9%) were female. Their mean age was 69.5 years. There was an increase in HI and reduction in SA starting at two and four weeks, respectively in the regenerative group. At 12 weeks, 61.7% (71/115) of ulcers treated with MEBO had complete healing (HI=1) versus 28.2% (29/103) of controls (p=0.000). None of the patients receiving MEBO had a HI of<0.5 at 12 weeks as compared to 25.2% of controls (p=0.000). Significantly (p<0.01) more grade 2-4 ulcers healed completely with MEBO by 12 weeks. No adverse effects or allergic reactions were noted by 12 weeks. Conclusion: In addition to its safety, MEBO significantly promotes the healing of CPUs with significant increase in HI of any given ulcer as early as two weeks of treatment, and significant reduction of ulcer SA starting at four weeks with complete healing of more than 60% of ulcers by 12 weeks.

摘要：Burns expose the deeper tissues of the skin or body to invasive microbes. Topical preparations for treating burn wounds, to be useful, should ideally have antibiotic power and promote healing. Silver compounds have been the mainstay of topical burn treatment for decades. However, most chemical substances retard wound healing. Several natural agents such as honey and moist exposed burn ointment (MEBO) are believed to protect wounds from infection and promote healing without causing any of the adverse effects of purified chemicals. In this study, we compared the wound healing properties of MEBO, a herbal preparation of Chinese origin, with silver sulphadiazine (SSD), a long-standing conventional burn dressing. Ten adult Sprague Dawley rats were divided into two groups. They were housed in separate cages and received partial-thickness burn wounds on their dorsal skin. They were then treated with MEBO and SSD. The wounds were inspected daily until day 8, when all the animals were sacrificed, perfused with normal saline, and had their wounds excised and prepared for histology. It was found that animals in both groups were well preserved. No clinical infections occurred. Wound healing was at an advanced stage by day 8 in all the animals. Clinical and histological examination showed that the two agents gave the animals comparable protection and healing possibilities. It is concluded that MEBO is a suitable and efficacious alternative to conventional silver-based topical therapies for treating partial-thickness burn wounds.

摘要：Backgrounds: Burn, a damage and tissue loss caused by heat with a high morbidity and mortality, have a many variation and complex problem that require special management. After a period of shock, there were infections that threaten the burn patients. These hazards aggravate the wound to become wider, and it affects the mortality and the length of stay. That is why to reduce mortality rate and length of stay, we need a proper wound care.Methods:A retrospective descriptive studies was perform on 2b degree burn patients (20-25%) that treated with tangential excision and mebo or tangential excision and stsg. Data was taken from burns unit Cipto Mangunkusumo hospital in period of January to December 2011.Results: There were 30 patients (73.2%) that have been treat with tangential excision and mebo, and 11 patients (26.8%) that have been treat with tangential excision and stsg. The average length of stay for the tangential excision and mebo is 22.47 ? 23 days(SD 4.361), whereas patients with tangential excision and stsg is 15.82 ?16 days (SD 2.089). There were 8 patients (26.7%) with tangential excision and mebo that die, whereas patients with tangential excision and stsg were 2 patients (18.2%) that die. There were significant difference in the average length of stay (p = 0.018), but there was no difference in the proportion of patients dying status (P = 0.611).Conclusion:Wound care by tangential excision and stsg on 2b degree burn patient (20-25%), have a better outcome than patients treated by tangential excision and mebo.