摘要：The present study aimed to compare between the use of platelet rich fibrin membrane (PRFM) and MEBO scar ointment for cutaneous wound healing as a model treatment. For this reason, forty two local breed rabbits have been divided into four groups, the first three groups were subjected to full thickness skin wound using biopsy punch instrument (diameter 8 mm) on the dorsal thoracic side. Rabbits in the first group leaved without treatment, while in the second group we planted the PRFM in biopsy site, the third group treated with MEBO scarointment. Wound healing process was observed grossly and microscopically at day 3, 7, 10 and 12 post operation.All groups showed normal healing process with competitive advantage to PRFM and MEBO groups respectively compared with untreated group, PRFM was better than the MEBO group, the advantage characterized by less inflammatory reaction, fast reepitheliazation, granulation tissue formation, fibroplasias, and angiogenesis.
摘要：To evaluate the therapeutic effects of moisture exposed burn ointment (MEBO) on phlebitis, seven electronic databases where checked until September, 2016 for randomized controlled trials (RCTs) of MEBO on phlebitis. Risk of bias was assessed using Cochrane handbook guidelines. Thirty eight randomized controlled trials met the inclusion criteria in which the aggregated results indicated that comparison revealed significant differences in total effectiveness rate of MEBO versus conventional therapy (RR=1.27, 95% confidence interval [CI]=1.06, 1.52, and P=0.009), and there were some beneficial evidence regarding the effects on reducing incidence of phlebitis MEBO versus conventional therapy in preventing phlebitis (RR=2.73, 95% confidence interval [CI]=1.94, 3.85, and P<0.00001). The evidence that MEBO is an effective treatment for phlebitis is encouraging, but not conclusive due to the low methodological quality of the RCTs. Therefore, more high-quality RCTs with larger sample sizes are required. Key words: External application of moisture exposed burn ointment, prevention and (or) treatment, phlebitis.
摘要：Background: This is still a public problem that needs to be solved urgently: chronic and refractory wound healing with long course and complex pathological mechanism. At present, there is still a lack of effective clinical treatment. This study, therefore, aims at exploring moist exposed burn therapy/moist exposed burn ointment (MEBT/MEBO) combined with Zhuang medicine detoxification in the treatment of chronic refractory wound healing. Methodology: 100 SPF Wistar rats were randomly divided into blank control group, model control group, MEBO group, Zhuang medicine group and Combined group, with 20 rats in each group. Open wound model was established in blank control group, and chronic refractory wound model was established in other groups. Black control group and model control group were given food and water freely, MEBO group was given dressing change once a day, Zhuang medicine group was given intragastric administration once a day, and combined group was given dressing change and intragastric administration once a day. The effective rate of wound healing was observed after 12 days of continuous intervention. Conclusion: Skin regeneration medical technique combined with Zhuang medicine poison theory can effectively reduce the symptoms of bleeding and exudation, reduce the area of wound, shorten the healing time of wound, and achieve physiological healing of wound. It has a good effect on chronic refractory wound.