摘要：The time profile of total proteins and albumin in line with two amino acids, Phe and Glu, are of great importance due to their indicative value of the healing and/or deterioration of burn wounds. In this experiment, rats exposed to scalding that produced a second-degree burn were divided into four groups: control, placebo, MEBO ointment, and copper (I) nicotinate complex ointment (an antioxidant anti-inflammatory) for four weeks. The three treatments showed noticeable similarities in the Phe profiles, with a slight drop 24 hours post burn, a peak elevation by the second week, and a slight, insignificant decline by the third week, with the placebo group showing highest values over normal (P< 0.05). In the Glu profile, large differences were observed: two set profiles, one representing MEBO and copper (I) nicotinate showed one peak in the second week, and the other representing placebo showed two peaks in the first and third weeks. Albumin and total protein time profiles showed the same trend throughout the whole experiment, and are in line with a reformed metabolic state parallel to wound closure. These results reveal that MEBO and copper nicotinate have comparable effects on wound healing in scald burns, and that plasma Glu profile is a better systemic indicator reflecting the regularity and steadiness of the healing process in MEBO and copper complex treatment.
摘要：Objective: Hard-to-heal wounds are a global health challenge, and effective treatments are still lacking. Moist exposed burn ointment (MEBO) and maggots are traditional treatments for promoting wound healing. This study was a preliminary exploration of combined maggot therapy and MEBO in the treatment of hard-to-heal wounds.Method: A coexistence experiment was conducted to determine the survival rates of maggots in MEBO. The maggots were placed in two different existence conditions: one set in MEBO (MEBO group), and another set as the control group (no MEBO) to compare survival rates. Case reports describe the use of the combined application of MEBO and maggots in the treatment of patients with hard-to-heal wounds.Results: The coexistence experiment indicated that maggots in the MEBO group had a higher survival rate. From the therapeutic effect of the clinical cases (n=7), the combined application was safe and effective, with all the reported wounds eventually healing.Conclusion: Based on the findings of this study, we believe the combined application of MEBO and maggots is a promising way of promoting wound healing. Further studies and clinical trials are needed to elucidate the mechanism of the combined application in promoting wound healing and to more persuasively clarify the therapeutic effect.
摘要：目的探讨CO2点阵激光联合湿润烧伤膏治疗面部色素沉着的临床效果及安全性。方法选取河南整形美容医院2021 年10 月至2023 年10 月收治65 例面部色素沉着患者，依据治疗方式不同分为对照组（n=33）、观察组（n=32）。对照组接受CO2点阵激光治疗，观察组接受CO2点阵激光联合湿润烧伤膏，两组均治疗至创面愈合。比较两组面部色素沉着评分、皮肤性质评分、生活质量评分、氧化应激指标、不良反应等。结果 治疗后两组面部色素沉着评分、皮肤性质评分均比治疗前高，且观察组比对照组更高；治疗后两组生活质量评分均比治疗前高，且观察组比对照组更高；治疗后两组血清丙二醛、过氧化脂质水平均比治疗前低，且观察组比对照组更低，血清超氧化物歧化酶均比治疗前高，且观察组比对照组高；观察组治疗期间不良反应总发生率比对照组更低，上述数据差异均有统计学意义（P<0.05）。结论 CO2点阵激光联合湿润烧伤膏可改善面部色素沉着患者皮肤性质，促进色素沉着恢复，调节氧化应激指标水平，提高患者生活质量，安全性较高。