摘要：目的对比观察不同温度的湿润烧伤膏（moist exposed burn ointment,MEBO）对超脉冲CO2点阵激光术后创面的修复效果。方法将2016年11月—2017年1月中山市中医院皮肤科、南方医科大学皮肤病医院皮肤外科与皮肤肿瘤科及中山市黄圃人民医院皮肤科收治的62例面部光老化患者随机分为常温组（30例）与低温组（32例）,其中常温组患者于超脉冲CO2点阵激光术后采用28℃的MEBO治疗术后创面;低温组患者于超脉冲CO2点阵激光术后采用4℃的MEBO治疗术后创面,对比观察两组患者创面开始脱痂时间、创面愈合时间及肤质改善情况。结果常温组患者创面开始脱痂时间为（3.80±0.71）d,创面愈合时间为（9.17±0.83）d,低温组患者创面开始脱痂时间为（4.41±1.07）d,创面愈合时间为（9.84±1.61）d,两组对比。t'值分别为2.660及2.078,P均<0.05,差异具有统计学意义;VISIA皮肤检测仪检测数据分析结果显示,治疗1个月后,常温组患者皮肤斑点（t=5.199）、紫外线色斑（t'=8.725）、纹理（t=3.701）、毛孔（t'=4.080）及皱纹（t=3.873）等肤质改善程度明显优于低温组,P均<0.01,差异具有统计学意义。结论不同温度的MEBO对超脉冲CO2点阵激光术后创面的修复效果存在差异,28℃的MEBO更适宜激光术后创面的修复。

摘要：目的初步评估不同温度的湿润烧伤膏（moist exposed burn ointment,MEBO）对大鼠超脉冲CO2点阵激光术后皮肤屏障功能的影响。方法按照随机数表法将30只Wistar大鼠随机分为空白对照组、正常对照组、冷敷组、MEBO低温组、MEBO常温组,每组6只。空白对照组大鼠仅做背部备皮处理,正常对照组、冷敷组、MEBO低温组及MEBO常温组大鼠均建立超脉冲CO2点阵激光术后创面模型,建模成功后正常对照组大鼠创面不做任何处理;冷敷组大鼠创面予以4℃水袋外敷30 min,每天1次;MEB0低温组大鼠创面予以4℃MEBO外涂,每天换药1次;MEBO常温组大鼠创面予以28℃MEBO外涂,每天换药1次。对比观察激光术前及激光术后即刻、12 h、24 h、7 d各组大鼠皮肤或创面经皮水分丢失（transepidermal water loss,TEWL）值。结果激光术后,正常对照组、冷敷组、MEBO低温组、MEBO常温组大鼠创面TEWL值均呈先升高后降低的趋势（F=66.740、106.100、91.080、70.860,P均=0.000,P均<0.05）,至激光术后7 d,正常对照组与MEBO常温组大鼠创面TEWL值均恢复至与术前相当的水平（P均>0.05）。激光术后即刻、12 h、24 h,正常对照组、冷敷组、MEBO低温组、MEBO常温组大鼠创面TEWL值均明显高于空白对照组（P均<0.05）,且冷敷组与MEBO低温组大鼠创面TEWL值明显高于正常对照组（P均<0.05）;激光术后7d,除MEBO常温组大鼠创面TEWL值基本恢复至空白对照组水平（P>0.05）,且明显低于正常对照组、冷敷组与MEBO低温组（P均<0.05）外,其余各组大鼠创面TEWL值均明显高于空白对照组（P均<0.05）。结论大鼠超脉冲CO2点阵激光术后创面会出现皮肤屏障功能受损,而常温（28℃） MEBO可加快创面愈合,促进皮肤屏障功能恢复正常。

摘要：目的:观察超脉冲CO2激光点阵疗法联合药物注射治疗增生性瘢痕的临床疗效。方法:55例增生性瘢痕患者,其中烧伤瘢痕27例,创伤、手术后瘢痕15例,痤疮瘢痕7例,其他瘢痕6例。采用超脉冲CO2点阵激光扫描(CW,ActiveFX、DeepFX、SCAAR FX模式),术毕采用美宝烧伤湿润膏外涂2周,治疗周期间隔3月,治疗疗程3～8次;激光治疗间隔期间根据瘢痕情况行复方倍他米松与5-Fu联合注射治疗。比较患者治疗前后瘢痕疼痛、瘙痒指数、创面愈合时间、色素沉着发生率,温哥华瘢痕量表评分。结果:患者瘢痕的临床疼痛瘙痒感明显好转,温哥华瘢痕量表评分和色素沉着发生率均优于治疗前,差异均有统计学意义(p<0.05)。结论:超脉冲CO2激光点阵疗法联合药物注射可有效治疗增生性瘢痕。

摘要：Background and Aim: Natural topical products have been used to enhance wound healing, especially in immunocompromised animals. The aims of this study were to evaluate and to compare the effects of moist exposed burn ointment (MEBO) and honey on the healing of full-thickness skin wounds in immunocompromised dogs. Materials and Methods: The study was conducted using 12 adults, apparently healthy mongrel dogs. Immunosuppression was induced in six dogs by oral administration of prednisone (2 mg/kg) and azathioprine (2 mg/kg), once a day for 21 days. On each dog, a total of 9, 1.5 cm in diameter full-thickness skin circular wounds were created aseptically in the thoracolumbar area under general anesthesia using customized skin punch biopsy kit. In a random fashion, three wounds in each dog were treatment using MEBO (contains b-sitosterol, baicalin, and berberine as active ingredients in a base of beeswax and sesame oil), honey or no treatment (control), once per day for 21 days. Wounds were grossly evaluated once a day for signs of inflammation or infection. In addition, biopsy specimens and digital imaging data of each wound were obtained on days 7, 14, and 21 for histopathological evaluation of the healing process. Results: Wounds in immunocompromised dogs appeared to heal significantly in a slower fashion than in non-immunocompromised counterparts. Digital analysis data showed that MEBO-treated wounds expressed better epithelialization area, faster contraction, and smaller wound area percentage when compared with honey-treated wounds. Histopathological analysis showed significantly higher angiogenesis scores in MEBO-treated wounds when compared with other treatments. Conclusion: Results of this study showed that MEBO resulted in significant enhancement of wound healing in both healthy and immunocompromised dogs. However, when compared to honey, the wound healing effect of MEBO was superior to that of honey.