摘要：The porcine model was used to investigate the wound healing process. 116 partial and full-thickness wounds were induced on the back of the animals using the CO2 Three local dressing agents were tested: Povidone Iodine, Silver Sulphadiazine and MEBO ointments. The following parameters were evaluated: physical examination, photography, pH, transepidermal water loss and moisture of the wound, planimetry and histological assessment of injury. The measurement of different parameters revealed that partial-thickness burn wounds were better assessed using Transepidermal Water Loss (TEWL), while full-thickness ones are better assessed using planimetry, measuring the surface of the wound. MEBO significantly accelerates the wound healing process of partial- (inflicted by CO2 Laser) and full-thickness excised wounds when compared to other local agents applied on wounds similar in size, extent and cause and the control group.

摘要：Background:Hand-foot syndrome (HFS), also known as palmoplantar erythrodysesthesia, is a common adverse effect of the fluoropyrimidine chemotherapy agent capecitabine. Hand-foot syndrome of any grade is reported to affect 43% to 71% of patients treated with single-agent capecitabine chemotherapy. Although not life-threatening, it can have adverse effects on the quality of life (QoL) and daily living activities of a patient.  Sometimes the dose interruptions and reductions required after observation of HFS can also impact on dose intensity and treatment outcomes.  As an option for the treatment of this case, we would reported our preliminary study of the effectiveness of moist exposed burn ointment (MEBO) for stage II and III HFS.   Methods:  We will evaluate the clinical sign and symptoms of hand foot syndrome grade II and III associated with capecitabine as adjuvant chemotherapy agent on advanced stage colorectal cancer.  All patients with HFS will treated with topical MEBO twice daily, the clinical improvement of the symptoms will be recorded.   Results: We reported 8 cases of grade II and III hand foot syndrome, 2 patients were grade III HFS and the others were grade II.  These symptoms occurred after 2 until 3 months after capecitabine administration for locally advanced (stage III) colonic adenocarsinoma.  Topical MEBO were used twice a day for 3 months, pain reduction was achieved with no capicetabine dose interruption and reduction during chemotherapy period.  Allergic reaction was not found during and after MEBO application in this case.   Conclusion:Moist exposed burn ointment was an effective treatment option in managing hand foot syndrome, better option in reducing the pain without interrupting the capecitabine doses.

摘要：The myofibroblast, a major component of granulation tissue, is a key cell during wound healing, tissue repair and connective tissue remodelling. Persistence of myofibroblasts within a fibrotic lesion leads to excessive scarring impairing function and aesthetics. Various wound-healing cytokines can be modulated by topical application of active agents to promote optimal wound healing and improve scar quality. Thus, the myofibroblast may represent an important target for wound-healing modulation to improve the evolution of conditions such as hypertrophic scars. The purpose of this work is to study the modulation of myofibroblasts and integrin αvβ3 in a full thickness wound performed on rabbits treated with different topical agents using: (1) saline, (2) Tegaderm occlusive dressing (3) silver sulfadiazine and (4) moist exposed burn ointment (MEBO). The reepithelialisation was 4 days faster in the MEBO group compared with the other therapies with less oedema formation, delayed contraction, less inflammatory cells and the lowest transepidermal water loss (TEWL) resulting in a soft scar. Although α-smooth muscle actin (α-SMA) was the highest around day 12 in the MEBO group, wound contraction and myofibroblast's activity were the least for the same period probably because of a downregulation of the integrin αvβ3. It seems that the effect of MEBO could be more pronounced on force transmission rather then on force generation. Greater insight into the pathology of scars may translate into non surgical treatments in the future and further work in myofibroblast biology will eventually result in efficient pharmacological tools, improving the evolution of healing and scar formation.

摘要：Burn injuries are associated with anatomically within physiologically infections and biochemically within immunologically defect in hepatic functions during direct action on locally and systematic role of blood elements and liver enzymes. These defects represented the cellular response due to burn injuries. Aim of study: to assess the treatment and antioxidant action of MEBO ointment in medical therapy ,such as burn therapy. Methods: The study was performed by 66 burn patents(male) received treatment with ointment MEBO(100g)twice daily for two weeks and all patients have thickness burn injury, age ranged(15-65years for all subjects) and 50 men healthy control subjects ,So one day post burn samples were collected for hematological &biochemical parameters in kirkuk city at Azaadi hospital ,and this study done from march to December 2019 . Results: Leukocytes count (WBC), Neutrophil, lymphocyte,) and erythrocyte sedimentation rate ( ESR) were increased, while red blood cells count (RBC), hemoglobin (HB) were decreased after burn injury. Creatinine and potassium element are increased significantly, while Sodium element was decreased and significantly increased in the liver enzyme and glutathione after treatment when MDA significantly decreased .Conclusion: This study concluded that blood parameters and liver functions were altered due to burn injuries and these modulations attributable to the lipid peroxidation(MDA), while the liver enzyme signaling of hepatic activity for glutathione synthesis for curbing the free radicals after treatment by MEBO ointment ,this productive mechanism may be new defect liver mechanism for burn injury.