摘要：<正>2016年11月18日,由美国商务部、美国徐荣祥基金会和美国加州州立大学洛杉矶分校联合设立的"徐荣祥生物科学创新中心(Rongxiang Xu Bioscience Innovation Center)"在美国加州州立大学洛杉矶分校举行了奠基仪式。美国国会议员赵美心、刘云平、Lucille Roybal-Allard,加州财务长江俊辉,加州众议员陈立德、Jimmy Gomez,美国徐荣祥基金会执行总裁徐鹏、主席

摘要：目的:探讨MEBO半暴露与INN促痂两种治疗方案对颜面部合并耳廓部位深度烧伤患者愈合效果、疼痛程度及炎性细胞因子的影响。方法:研究对象选取丽水市人民医院2014年3月-2016年3月收治颜面部合并耳廓部位深度烧伤患者共100例,以随机抽签法分为对照组(50例)和观察组(50例),分别采用INN促痂和MEBO半暴露疗法治疗;比较两组患者创面愈合效果,创面愈合时间,创面病原菌转阴换药次数,治疗前后VAS评分,TNF-α,IL-6及IL-8水平等。结果:观察组患者创面愈合效果显著优于对照组(P<0.05);观察组患者创面愈合时间和创面病原菌转阴换药次数均显著优于对照组(P<0.05);两组患者治疗后7d、14d及28dVAS评分均显著低于治疗前(P<0.05);观察组患者治疗后7d、14d及28dVAS评分均显著低于对照组(P<0.05);两组患者治疗后炎症细胞因子水平均显著高于治疗前(P<0.05);观察组患者治疗后炎症细胞因子水平均显著低于对照组(P<0.05)。结论:MEBO半暴露疗法治疗颜面部合并耳廓部位深度烧伤可有效促进创面愈合,减轻疼痛程度,并有助于下调炎性细胞因子水平,价值优于INN促痂疗法。

摘要：Ethnopharmacological relevance The diabetic wound is one of the common chronic complications of diabetes, which seriously affects patients’ quality of life and even causes disability and death. Traditional Chinese medicine (TCM) is a unique and precious resource in China, which has a good curative effect and safety. At present, it has been found that Chinese herbal compounds and effective active ingredients can effectively promote diabetic wound healing, and its mechanism needs to be further studied. Signaling pathways are involved in the pathogenesis and progression of diabetic wounds, which is one of the main targets for the pathologic mechanism of diabetic wounds and the pharmacological research of therapeutic drugs. Aim of the review This study has been carried out to reveal the classical signaling pathways and potential targets by the action of TCM on diabetic wound healing and provides evidence for its clinical efficacy. Materials and methods “diabetic wound”, “diabetic foot ulcer”, “traditional Chinese medicine”, “natural plant” and “medicinal plant”, were selected as the main keywords, and various online search engines, such as PubMed, Web of Science, CNKI and other publication resources, were used for searching literature. Results The results showed that TCM could regulate the signaling pathways to promote diabetic wound healing, such as Wnt, Nrf2/ARE, MAPK, PI3K/Akt, NF-κB, Notch, TGF-β/Smad, HIF-1α/VEGF, which maintaining inflammatory interaction balance, inhibiting oxidative stress and regulating abnormal glucose metabolism. Conclusion The effect of TCM on diabetic wound healing was reflected in multiple levels and multiple pathways. It is envisaged to carry out further research from precision-targeted therapy, provide ideas for screening the core target of TCM in treating diabetic wounds and create modern innovative drugs based on this target.

摘要：Cosmetic, functional, and structural sequelae of scarring are innumerable, and measures exist to optimize and ultimately minimize these sequelae. To evaluate the innumerable methods available to decrease the cosmetic, functional, and structural repercussions of scarring, pubMed search of the English literature with key words scar, scar revision, scar prevention, scar treatment, scar remodeling, cicatrix, cicatrix treatment, and cicatrix remodeling was done. Original articles and reviews were examined and included. Seventy-nine manuscripts were reviewed. Techniques, comparisons, and results were reviewed and tabulated. Overall, though topical modalities are easier to use and are usually more attractive to the patient, the surgical approaches still prove to be superior and more reliable. However, advances in topical medications for scar modification are on the rise and a change towards medical treatment of scars may emerge as the next best approach. Comparison studies of the innumerable specific modalities for scar revision and prevention are impossible. Standardization of techniques is lacking. Scarring, the body's natural response to a wound, can create many adverse effects. At this point, the practice of sound, surgical fundamentals still trump the most advanced preventative methods and revision techniques. Advances in medical approaches are available, however, to assist the scarring process, which even the most advanced surgical fundamentals will ultimately lead to. Whether through newer topical therapies, light treatment, or classical surgical intervention, our treatment armamentarium of scars has expanded and will allow us to maximize scar prevention and to minimize scar morbidity.