摘要：目的 :本多中心临床试验在 6个国家的 2 0个医疗单位观察了不同严重程度的烧伤病人 1 38例 ,共计不同原因烧伤的、不同深度和不同部位的烧伤创面 566处 ,其目的在于评价临床应用湿润烧伤膏 (MEBO)治疗烧伤创面的疗效。方法 :试验观察参数及评价指标包括 :( 1 )创面愈合时间 ;( 2 )是否需要止痛剂 ;( 3)静脉输液量 ;( 4 )是否需要全身使用抗生素 ;( 5)创面愈合后外观。结果 :所有创面的愈合时间明显缩短。除少数深Ⅱ度和Ⅲ度烧伤外 ,大多数病人不需要任何止痛剂 ,或者只需要作用温和的止痛剂。静脉输液量显著减少。只有 1 9%的病例出现临床感染症状 ,且主要是那些烧伤后没有立即采用MEBO治疗者 ;尽管多数病例均按常规预防性全身使用抗生素 ,但仍有 32例未给予任何抗生素且均未发生感染。创面愈合后外观非常满意。结论 :使用MEBO治疗烧伤 ,创面愈合较快 ,创面感染少 ,愈合后外观好 ,病人非常满意。

摘要：One hundred and thirty-eight (138) patients, with five hundred and sixty-six (566) different burn sites with different degrees, severity and locations, were enrolled to a multicenter clinical trial at 25 study centers. The goal of this trial was to evaluate the efficacy of MEBO (Moist Exposed Burn Ointment) in the treatment of burn wound. Various parameters were studied including: (i) healing time, (ii) need for pain killers, (iii) consumption of i. v. Fluids, (iv) use of systemic antibiotics and (v) aesthetic appearance. There was remarkable decrease in the healing time and most patients either did not need any pain killer or were relieved with only mild analgesics, except in few cases of deep second degree and third degree burns. A decrease in the volume of i. v. fluids needed was also reported. Only 19% of cases developed clinical infection, especially in those who were not treated with MEBO immediately post burn. Even though systemic antibiotic treatment was prophylactically implemented in most cases as a routine measure, 32 cases did not receive any antibiotic prophylaxis with MEBO and yet did not develop any infection. The aesthetic appearance reported was very acceptable. This treatment modality was not associated with any side effects, and patient discomfort during application and change was negligible. Thus, MEBO treatment was associated with excellent and relatively faster healing, low incidence of wound infection, and excellent patient compliance.