摘要：The presence of necrotic tissue is one of the major problems that affect healing of burn wounds. The present study was designed to find the effectiveness of collagenase versus moist exposed burn ointment (MEBO) on removal of necrotic tissue of burns. Twenty mice randomly assigned and divided into four groups. For Group 1, burn wounds were treated with collagenase ointment only, Group 2 burn wounds were treated with MEBO, Group 3 burn wounds were treated with white vaseline alone, and Group 4 burn wounds were considered as control and left without treatment. In each group, the time of treatment was considered. The results indicated that the removal time of necrotic tissue and healing process was better in the case of using collagenase than using MEBO for treatment of burns.

摘要：Healing Second degree burns can be affected by the presence of bacteria. This research reveals the role of honey and MEBO in removing bacterial effects on healing. Pure experimental research method with a completely randomized design (CRD). There were 4 treatments, which were positive, negative, honey and MEBO treatment, each of which was given to rats with second degree burns. Wound healing and other parameters were observed on 7th, 14th and 21st days. The result was that the administration of honey as an antibacterial drug was very effective and gave healing on the 21st day to white rats. Giving MEBO as an antibacterial drug is very effective and provides healing on the 21st day to white rats. Giving honey is more effective than MEBO as an antibacterial drug and healing burns on 21st day against white rats.

摘要：Skin wounds represent an enormous clinical and financial problem in equine. The present study evaluated the effect of Panthenol gel and Mebo ointment on metacarpal wounds healing in donkeys. This experimental study was carried out on eighteen adult donkeys divided into three groups each of six donkeys. All animals were exposed to creation of 2?× 2 cm full-thickness skin wound on the dorsal aspect of the metacarpal regions of both forelimbs. All the wounds were cleaned daily with sterile gauze soaked with sterile distilled water. For the Panthenol gel group, 1 finger tip unit (0.5?g) of Panthenol gel was applied once daily over the wound surfaces. For the Mebo ointment group, 1 finger tip unit (0.5?g) of Mebo ointment was applied once daily over the wound surfaces. For control group, the wounds were cleaned with sterile gauze soaked with sterile distilled water without application of any treatment. The wound healing process was compared by gross observation, geometrical assessments of percentage wound contraction, percentage wound epithelialization, percentage wound healing, and histopathological examination. The wound contraction, wound epithelialization, and wound healing percentages in the Panthenol gel group were significantly higher than other groups and by the end of seventh week, all animals’ wounds in the Panthenol gel group had complete healing. Mebo ointment group had no a significant effect on wound epithelialization and wound healing percentages. In conclusion, the study recommended the use of Panthenol gel as an effective and low-cost wound healing promoting agent for full-thickness skin wounds in donkeys.

摘要：The time profile of total proteins and albumin in line with two amino acids, Phe and Glu, are of great importance due to their indicative value of the healing and/or deterioration of burn wounds. In this experiment, rats exposed to scalding that produced a second-degree burn were divided into four groups: control, placebo, MEBO ointment, and copper (I) nicotinate complex ointment (an antioxidant anti-inflammatory) for four weeks. The three treatments showed noticeable similarities in the Phe profiles, with a slight drop 24 hours post burn, a peak elevation by the second week, and a slight, insignificant decline by the third week, with the placebo group showing highest values over normal (P< 0.05). In the Glu profile, large differences were observed: two set profiles, one representing MEBO and copper (I) nicotinate showed one peak in the second week, and the other representing placebo showed two peaks in the first and third weeks. Albumin and total protein time profiles showed the same trend throughout the whole experiment, and are in line with a reformed metabolic state parallel to wound closure. These results reveal that MEBO and copper nicotinate have comparable effects on wound healing in scald burns, and that plasma Glu profile is a better systemic indicator reflecting the regularity and steadiness of the healing process in MEBO and copper complex treatment.