摘要：Background and Aim: Natural topical products have been used to enhance wound healing, especially in immunocompromised animals. The aims of this study were to evaluate and to compare the effects of moist exposed burn ointment (MEBO) and honey on the healing of full-thickness skin wounds in immunocompromised dogs. Materials and Methods: The study was conducted using 12 adults, apparently healthy mongrel dogs. Immunosuppression was induced in six dogs by oral administration of prednisone (2 mg/kg) and azathioprine (2 mg/kg), once a day for 21 days. On each dog, a total of 9, 1.5 cm in diameter full-thickness skin circular wounds were created aseptically in the thoracolumbar area under general anesthesia using customized skin punch biopsy kit. In a random fashion, three wounds in each dog were treatment using MEBO (contains b-sitosterol, baicalin, and berberine as active ingredients in a base of beeswax and sesame oil), honey or no treatment (control), once per day for 21 days. Wounds were grossly evaluated once a day for signs of inflammation or infection. In addition, biopsy specimens and digital imaging data of each wound were obtained on days 7, 14, and 21 for histopathological evaluation of the healing process. Results: Wounds in immunocompromised dogs appeared to heal significantly in a slower fashion than in non-immunocompromised counterparts. Digital analysis data showed that MEBO-treated wounds expressed better epithelialization area, faster contraction, and smaller wound area percentage when compared with honey-treated wounds. Histopathological analysis showed significantly higher angiogenesis scores in MEBO-treated wounds when compared with other treatments. Conclusion: Results of this study showed that MEBO resulted in significant enhancement of wound healing in both healthy and immunocompromised dogs. However, when compared to honey, the wound healing effect of MEBO was superior to that of honey.

摘要：目的:研究VAC(持续负压封闭吸引技术)联合MEBO(美宝湿润性烧伤膏)在难愈性创面治疗中的应用.方法:选取2017年5月至2018年5月我院持续30天以上发生46处创面的40例住院患者,进行负压封闭吸引技术7天,依据创面的情况决定是否进行再次吸引,等待难愈性创面长出新鲜肉芽后,把美宝湿润性烧伤膏外敷在创面上,肉芽愈合后进行植皮修复术修复创面.结果:在本次研究中,经过VAC联合MEBO治疗后创面愈合的患者有18例,创面肉芽组织生长较好后进行植皮修复手术20例,糖尿病足患者在治疗过程中因经济原因放弃治疗2例.结论:采用VAC联合MEBO治疗难愈性创面中,能更好地促进创面的愈合和减少患者的住院时间,为治疗各种难愈性创面提供有效的治疗方法.

摘要：选取42例住院患者46处持续1月以上的创面,行常规清创术,使用VAC吸引覆盖创面,行负压吸引1周,据创面情况决定是否再次吸引,待创面有新鲜肉芽生长后,行美宝烧伤膏外敷创面,肉芽丰满后行游离植皮手术修复创面。21例患者自行愈合,20例患者经游离皮片移植,1例糖尿病足患者治疗过程中放弃治疗。VAC联合MEBO治疗技术较传统换药、湿敷、单独应用VAC或MEBO的方法,更有效促进创面愈合,缩短患者住院治疗时间,为各种难愈性创面的修复提供治疗方法。

摘要：Introduction: Handfoot syndrome is a side effect of Capecitabine chemotherapy. It highly effects the quality of patients’ life due to the pain and swelling of the hand and foot. Previous studies had proven Moist Exposed Burn Ointment (MEBO) as an ideal regiment for several skin pathologies. Here, we report 8 cases of grade II and III hand foot syndrome treated with topical MEBO.