摘要：Burn injury is one of the most devastating injuries that may affect a patient. Even in economically deprived areas, burn care is largely driven by relatively plentiful resources equating quality of care with generous monitoring and clinical attention with little concern to management cost. Burn care costs have been the subject of very few investigations and are among the least studied by health services researchers. Nevertheless, it can be stated that local care of burn wounds accounts for a large proportion of the cost per day for treating patients. As economic times are changing and as market penetration of managed care contracts and stiff competition in the health care industry gains momentum, ways to reduce expenditures without adversely affecting the quality of care have become of primary importance. We report a randomized prospective comparative study analyzing the benefit-cost value of moist exposed burn ointment (MEBO) application, an exposed method for burn wound care without the need for a secondary covering dressing, as compared to conventional closed methods.

摘要：目的观察APP指导下湿润烧伤膏对门诊四肢皮肤擦挫伤后结痂创面的临床疗效。方法选取来我院门诊就诊的2016年1月—2017年12月的患者,笔者应用MEBO治疗挫擦伤结痂患者45例,全程采用APP手机软件进行指导用药,创面简单清创后采用湿润烧伤膏换药治疗。结果结合APP软件的指导,解决了患者就诊中的困难,患者应用湿润烧伤膏具有消肿迅速,无痛溶痂、恢复时间短、患者容易接受等优点。结论湿润烧伤膏治疗皮肤挫擦伤结痂创面疗效显著,具有不手术、无疼痛、愈合快等优点。APP软件指导下应用湿润烧伤膏治疗皮肤挫擦伤具有方法简单、安全,疗效好,可操作性强的优点,值得推广使用。

摘要：This study explored the effects of Moist Exposed Burn Ointment (MEBO) on the healing process of pressure-induced wounds. Using a stage IV pressure ulcer model established in 42 rats, divided equally into a control gel group and an MEBO group, we investigated the efficacy of MEBO through topical application. The control group received Carbomer gel, while the MEBO group was treated with MEBO until complete wound healing. Results showed that MEBO significantly accelerated wound healing compared to the control group. Histological analysis, including hematoxylin and eosin (HE) staining and Masson’s trichrome staining, revealed enhanced epithelialization and collagen deposition in the MEBO group. Furthermore, 16S rRNA sequencing indicated that MEBO reduced microbial diversity at the wound site and reshaped the microbial composition. Notably, The increased abundance of Acinetobacter and Staphylococcus, coupled with a reduction in Pseudomonas, may reflect a shift in the wound microbiome that could be conducive to healing. However, the exact role of these microbial shifts in promoting wound healing requires further investigation, as microbial dynamics in wound environments are complex and context-dependent. These findings suggest that MEBO facilitates wound healing by optimizing the wound microbiome, thereby offering a promising therapeutic approach for managing pressure ulcers.

摘要：Method: Consecutive patients (n=105) with CPUs (n=218) treated at three different hospitals were randomized to receive Moist Exposed Burn Ointment (MEBO) dressings (Regenerative group, n=55 with 115 ulcers) or wet-to-moist saline dressings (Control group, n=50 with 103 ulcers). Data collected prospectively included demographics, clinical, biochemical and ulcer features. Ulcer surface area (SA) and healing index (HI) were calculated and compared at twoweek intervals for 12 weeks. Results: Sixty-one patients (58.1%) were male and 44 (41.9%) were female. Their mean age was 69.5 years. There was an increase in HI and reduction in SA starting at two and four weeks, respectively in the regenerative group. At 12 weeks, 61.7% (71/115) of ulcers treated with MEBO had complete healing (HI=1) versus 28.2% (29/103) of controls (p=0.000). None of the patients receiving MEBO had a HI of<0.5 at 12 weeks as compared to 25.2% of controls (p=0.000). Significantly (p<0.01) more grade 2-4 ulcers healed completely with MEBO by 12 weeks. No adverse effects or allergic reactions were noted by 12 weeks. Conclusion: In addition to its safety, MEBO significantly promotes the healing of CPUs with significant increase in HI of any given ulcer as early as two weeks of treatment, and significant reduction of ulcer SA starting at four weeks with complete healing of more than 60% of ulcers by 12 weeks.