摘要：Background and Objectives:? MEBO is a Chinese burn ointment has been introduced recently for local management of burn injuries with a USA patented formulation since 1995. In this study we try to prove that MEBO is more effective if applied vaginally after electrocautery than electrocautery alone in treating cervical erosion. Method:? This study performed from 1st of May 2013 to the end of April 2014 in private clinic in Baghdad, a clinical comparative study was done on 100 patients who had cervical erosion (by clinical examination), group 1 (50 patients) were treated with electro cautery once time alone. group 2 treated with electrocautery once time followed by MEBO application vaginally once daily for 20 days, all patients in both groups seen weekly to assess the start and completion of healing of erosion and any sign of infection and improvement of any symptom especially vaginal discharge. Results:? The mean time required for start and completion of healing was significantly shorter for group 2 (1.5 ± 0.5)weeks,(2.2 ± 0.6)weeks, respectively than group1 which was (3.5 ± 1.0)weeks, (4.2 ± 1.0) respectively and it was statistically significant (P value less 0.001). More patients in group 2 had decreased vaginal discharge (44)than group1 (33) and it was statistically significant difference. Also the incidence of vaginal infection was less in group 2 (6%) than group1 (24%), it was significant statistical difference. More patients in group 2 healed completely (45) than group 1 (38) but the difference was statistically not significant. Conclusion:? MEBO is very efficacious in treating cervical erosion and is superior to electocautery alone.

摘要：Microskin graft is a technique of skin defect closure using a minimum of STSG donors to cover the large defect. Some considerations were taken, which includes the general status of the patient, donor area morbidity, and patient refusal to act is one of the reasons for the use microskin graft. History STSG failure with previous defect closure and lack of donor area would to bene!t from microskin graft. Case of boy 12 years old with extensive defects in the forearm due to burns. Consideration of the lack of donor area made us deciding to use microskin graft as main option to close the defect. We did one-week post operative evaluation. Epithelialization occurs at day 7, while complete epithelialization occurred at 14th day. Three month during follow-up control, the scar are minimal. We conclude that microskin graft is one technic that can be used in skin defect closure with minimal donor.

摘要：Objective: The goal of any topical formulation is efficient transdermal delivery of its active components. However, delivery of compounds can be problematic with penetration through tough layers of fibrotic dermal scar tissue.Approach: We propose a new approach combining high-performance liquid chromatography (HPLC) and Raman spectroscopy (RS) using a topical of unknown composition against a well-known antiscar topical (as control).Results: Positive detection of compounds within the treatment topical using both techniques was validated with mass spectrometry. RS detected conformational structural changes; the 1,655/1,446?cm?1 ratio estimating collagen content significantly decreased (p?<?0.05) over weeks 4, 12, and 16 compared with day 0. The amide I band, known to represent collagen and protein in skin, shifted from 1,667 to 1,656?cm?1, which may represent a change from β-sheets in elastin to α-helices in collagen. Confirmatory elastin immunohistochemistry decreased compared with day 0, conversely the collagen I/III ratio increased in the same samples by week 12 (p?<?0.05, and p?<?0.0001, respectively), in keeping with normal scar formation. Optical coherence tomography attenuation coefficient representing collagen deposition was significantly decreased at week 4 compared with day 0 and increased at week 16 (p?<?0.05).Innovation: This study provides a platform for further research on the simultaneous evaluation of the effects of compounds in cutaneous scarring by RS and HPLC, and identifies a role for RS in the therapeutic evaluation and theranostic management of skin scarring.Conclusions: RS can provide noninvasive information on the effects of topicals on scar pathogenesis and structural composition, validated by other analytical techniques.