摘要：AbstrakBerbagai penelitian ilmiah telah membuktikan bahwa kolagen merupakan biomaterial ideal dalam aktivitas penyembuhan luka. Senyawa bioaktif pada madu dan Aloe vera dapat membantu meningkatkan pembentukan kolagen. Penelitian ini dilakukan untuk membandingkan pengaruh aplikasi topikal madu, gel Aloe vera, dan Moist Exposed Burn Ointment (MEBO) terhadap kepadatan kolagen pada proses penyembuhan luka bakar derajat dua pada tikus. Luka bakar dibuat pada 28 ekor tikus dan dibagi menjadi empat kelompok yang dipilih secara acak serta dilakukan aplikasi topikal harian dengan NaCl, madu, gel Aloe vera, dan MEBO secara berurutan. Biopsi kulit dilakukan pada hari ke-7, kemudian dilakukan pembuatan sediaan histopatologi kulit dan dihitung kepadatan kolagennya. Uji One Way ANOVA menunjukkan kepadatan kolagen berbeda secara signifikan antar masing-masing kelompok (p= 0,009). Uji Post Hoc Bonferroni menunjukkan terdapat perbedaan yang signifikan antara kelompok NaCl dengan madu (p= 0,024) dan NaCl dengan MEBO (p= 0,024). Penelitian ini menunjukkan bahwa aplikasi madu dan MEBO secara topikal pada luka bakar derajat dua dapat meningkatkan pembentukan kolagen, sehingga dapat mempercepat proses penyembuhan luka. Madu, Aloe vera, dan MEBO dapat dijadikan sebagai terapi alternatif dalam penyembuhan luka bakar.?AbstractVarious scientific studies have proven that collagen is an ideal biomaterial in wound healing activities. The bioactive compounds in honey and Aloe vera can help increase collagen formation. This study was conducted to compare the effect of topical application of honey, Aloe vera gel, and MEBO (Moist Exposed Burn Ointment) on collagen density in the healing process of second-degree burns in rats. Burns were made on 28 rats which were further randomly divided into four groups to receive daily topical application of NaCl, Aloe vera, honey, and MEBO respectively. Skin biopsy was carried out on the seventh day, then histopathological preparation of the skin was made and collagen density was calculated. Result of One Way ANOVA test showed that collagen density differed significantly between groups (p= 0.009). The Post Hoc Bonferroni test resulted in significant difference between NaCl with honey group (p= 0.024) and NaCl with MEBO (p= 0.024). This study found that topical application of honey and MEBO to second-degree burns could increase collagen formation, thus accelerating wound healing process. Honey, Aloe vera, and MEBO can be used as alternative therapies for healing burns.

摘要：Safe cutaneous antisepsis in neonatal intensive care unit is imperative. Chlorhexidine-based solution is commonly used for skin preparation prior to the placement of intravascular devices. However, in premature infants, its usage has not been standardized. We present a case of chemical burns secondary to the use of chlorhexidine-alcohol skin preparation solution in an extremely low birth weight infant.

摘要：Skin wounds represent an enormous clinical and financial problem in equine. The present study evaluated the effect of Panthenol gel and Mebo ointment on metacarpal wounds healing in donkeys. This experimental study was carried out on eighteen adult donkeys divided into three groups each of six donkeys. All animals were exposed to creation of 2?× 2 cm full-thickness skin wound on the dorsal aspect of the metacarpal regions of both forelimbs. All the wounds were cleaned daily with sterile gauze soaked with sterile distilled water. For the Panthenol gel group, 1 finger tip unit (0.5?g) of Panthenol gel was applied once daily over the wound surfaces. For the Mebo ointment group, 1 finger tip unit (0.5?g) of Mebo ointment was applied once daily over the wound surfaces. For control group, the wounds were cleaned with sterile gauze soaked with sterile distilled water without application of any treatment. The wound healing process was compared by gross observation, geometrical assessments of percentage wound contraction, percentage wound epithelialization, percentage wound healing, and histopathological examination. The wound contraction, wound epithelialization, and wound healing percentages in the Panthenol gel group were significantly higher than other groups and by the end of seventh week, all animals’ wounds in the Panthenol gel group had complete healing. Mebo ointment group had no a significant effect on wound epithelialization and wound healing percentages. In conclusion, the study recommended the use of Panthenol gel as an effective and low-cost wound healing promoting agent for full-thickness skin wounds in donkeys.

摘要：<正>To extend clinical application of skin regeneration in .situ technique with MEBO on split skin thickness donor site a protocol was made for clinical study of treating skin donor site in skin regeneration is situ technique with MEBO in Octobcr of 2005 .The protocol was sent to hospitals that had carried out such study for their conducting the study .The data