Pharmacological modulation of wound healing in experimental burns
Jurjus, Abdo; Atiyeh, Bishara S.; Abdallah, Inaya M.; Jurjus, Rosalyne A.; Hayek, Shady N.; Jaoude, Marlene Abou; Gerges, Alice; Tohme, Rania A.
Human Morphology, Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanonb; Division Plastic and Reconstructive Surgery, American University of Beirut Medical Center, Beirut, Lebanon; Human Morphology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon; Immunofluorescence-Immunology, Faculty of Medicine, George Washington University, USA; Faculty of Phamnacy, St. Joseph University, Beirut, Lebanon; Faculty of Phamacy, Immunology Pharmacology, St. Joseph University, Beirut, Lebanon; Histology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
Burns
2007
摘要：Factors involved in wound healing and their interdependence are not yet fully understood; nevertheless, new prospects for therapy to favor speedy and optimal healing are emerging. Reports about wound healing modulation by local application of simple and natural agents abound even in the recent literature, however, most are anecdotal and lack solid scientific evidence. We describe the effect of silver sulfadiazine and moist exposed burn ointment (MEBO), a recently described burn ointment of herbal origin, on mast cells and several wound healing cytokines (bFGF, IL-1, TGF-β, and NGF) in the rabbit experimental burn model. The results demonstrate that various inflammatory cells, growth factors and cytokines present in the wound bed may be modulated by application of local agents with drastic effects on their expression dynamics with characteristic temporal and spatial regulation and changes in the expression pattern. Such data are likely to be important for the development of novel strategies for wound healing since they shed some light on the potential formulations of temporally and combinatory optimized therapeutic regimens.
