摘要：This study explored the effects of Moist Exposed Burn Ointment (MEBO) on the healing process of pressure-induced wounds. Using a stage IV pressure ulcer model established in 42 rats, divided equally into a control gel group and an MEBO group, we investigated the efficacy of MEBO through topical application. The control group received Carbomer gel, while the MEBO group was treated with MEBO until complete wound healing. Results showed that MEBO significantly accelerated wound healing compared to the control group. Histological analysis, including hematoxylin and eosin (HE) staining and Masson’s trichrome staining, revealed enhanced epithelialization and collagen deposition in the MEBO group. Furthermore, 16S rRNA sequencing indicated that MEBO reduced microbial diversity at the wound site and reshaped the microbial composition. Notably, The increased abundance of Acinetobacter and Staphylococcus, coupled with a reduction in Pseudomonas, may reflect a shift in the wound microbiome that could be conducive to healing. However, the exact role of these microbial shifts in promoting wound healing requires further investigation, as microbial dynamics in wound environments are complex and context-dependent. These findings suggest that MEBO facilitates wound healing by optimizing the wound microbiome, thereby offering a promising therapeutic approach for managing pressure ulcers.
摘要：Burns expose the deeper tissues of the skin or body to invasive microbes. Topical preparations for treating burn wounds, to be useful, should ideally have antibiotic power and promote healing. Silver compounds have been the mainstay of topical burn treatment for decades. However, most chemical substances retard wound healing. Several natural agents such as honey and moist exposed burn ointment (MEBO) are believed to protect wounds from infection and promote healing without causing any of the adverse effects of purified chemicals. In this study, we compared the wound healing properties of MEBO, a herbal preparation of Chinese origin, with silver sulphadiazine (SSD), a long-standing conventional burn dressing. Ten adult Sprague Dawley rats were divided into two groups. They were housed in separate cages and received partial-thickness burn wounds on their dorsal skin. They were then treated with MEBO and SSD. The wounds were inspected daily until day 8, when all the animals were sacrificed, perfused with normal saline, and had their wounds excised and prepared for histology. It was found that animals in both groups were well preserved. No clinical infections occurred. Wound healing was at an advanced stage by day 8 in all the animals. Clinical and histological examination showed that the two agents gave the animals comparable protection and healing possibilities. It is concluded that MEBO is a suitable and efficacious alternative to conventional silver-based topical therapies for treating partial-thickness burn wounds.
摘要：Backgrounds: Burn, a damage and tissue loss caused by heat with a high morbidity and mortality, have a many variation and complex problem that require special management. After a period of shock, there were infections that threaten the burn patients. These hazards aggravate the wound to become wider, and it affects the mortality and the length of stay. That is why to reduce mortality rate and length of stay, we need a proper wound care.Methods:A retrospective descriptive studies was perform on 2b degree burn patients (20-25%) that treated with tangential excision and mebo or tangential excision and stsg. Data was taken from burns unit Cipto Mangunkusumo hospital in period of January to December 2011.Results: There were 30 patients (73.2%) that have been treat with tangential excision and mebo, and 11 patients (26.8%) that have been treat with tangential excision and stsg. The average length of stay for the tangential excision and mebo is 22.47 ? 23 days(SD 4.361), whereas patients with tangential excision and stsg is 15.82 ?16 days (SD 2.089). There were 8 patients (26.7%) with tangential excision and mebo that die, whereas patients with tangential excision and stsg were 2 patients (18.2%) that die. There were significant difference in the average length of stay (p = 0.018), but there was no difference in the proportion of patients dying status (P = 0.611).Conclusion:Wound care by tangential excision and stsg on 2b degree burn patient (20-25%), have a better outcome than patients treated by tangential excision and mebo.