摘要：体表慢性难愈合创面(俗称溃疡)是由一系列创伤和疾病所致。这类创面具有病程长、对外观影响大以及并发症多等特点,成为外科学中的一大难点问题。研究表明烧伤湿性医疗技术(MEBT/MEBO)对烧(创)伤创面具有改善微循环、祛腐生肌、促进创面再生与修复作用。本文通过综述分析MEBT/MEBO与慢性难愈合创面bFGF、VEGF的关系,明确MEBT/MEBO对慢性难愈合创面促进血管、细胞生长,加速创面愈合的分子生物学机制,阐述其基础研究现状和展望。

摘要：体表慢性难愈合创面(俗称溃疡)是由一系列创伤和疾病所致,这类创面具有病程长、对外观影响大以及并发症多等特点。中医外治溃疡历史悠久,近年来,我们在临床上应用MEBT/MEBO治疗多种慢性难愈合皮肤创面,取得了较好的疗效[1]。本实验进一步探讨MEBT/MEBO对皮肤溃疡局部血管内皮细胞粗面内质网结构的影响,以期可以从不同侧面揭示

摘要：This meta-analysis aimed to assess the effectiveness of moist exposed burn ointment (MEBO) for diabetic foot ulcers (DFU). Two researchers independently assessed the quality and validity of included randomized controlled trials (RCTs) in 7 electronic databases. Risk of bias was assessed using Cochrane handbook guidelines. Twenty seven trials which include 1,979 patients were involved for analysis. Comparison of the same intervention strategies revealed significant differences in total effectiveness rates between BEBO and conventional therapy group (Risk Ratio [RR], 6.36, [95% confidence interval (CI), 3.20, 12.64], P < 0.00001); MEBO combined with standard therapy (Risk Ratio [RR], 1.19, [95% confidence interval (CI), 1.08, 1.31], P = 0.0007); and healing time of DFU (Mean Difference [MD], 14.15, [95% confidence interval (CI), -18.14, -10.17], P < 0.00001). MEBO may be effective for treating DFU. However, a firm conclusion could not be reached because of the poor quality of the included trials. Further trials with higher quality are justified.   Key words: Exposed wound ointment (MEBO), diabetic foot ulcers (DFU), recombinant bovine, basic fibroblast growth factor (rb-bFGF), vacuum sealing drainage (VSD).