摘要：Objective: Moist Exposed Burn Ointment (MEBO) is a kind of external preparation widely used in skin burn. We found that MEBO can also promote the healing of diabetes mellitus in silkworm feet. In order to further understand the mechanism of MEBO promoting skin healing, lable-free quantitative proteomics analysis is used to detect differential protein between MEBO groups and blank groups.

摘要：Factors involved in wound healing and their interdependence are not yet fully understood; nevertheless, new prospects for therapy to favor speedy and optimal healing are emerging. Reports about wound healing modulation by local application of simple and natural agents abound even in the recent literature, however, most are anecdotal and lack solid scientific evidence. We describe the effect of silver sulfadiazine and moist exposed burn ointment (MEBO), a recently described burn ointment of herbal origin, on mast cells and several wound healing cytokines (bFGF, IL-1, TGF-β, and NGF) in the rabbit experimental burn model. The results demonstrate that various inflammatory cells, growth factors and cytokines present in the wound bed may be modulated by application of local agents with drastic effects on their expression dynamics with characteristic temporal and spatial regulation and changes in the expression pattern. Such data are likely to be important for the development of novel strategies for wound healing since they shed some light on the potential formulations of temporally and combinatory optimized therapeutic regimens.

摘要：Conventional management of partial-thickness burn wounds includes the use of paraffin gauze dressing, frequently with topical silver-based antibacterial creams. Some creams form an overlying slough that renders wound assessment difficult and are painful upon application. An alternative to conventional management, moist exposed burn ointment (MEBO), has been proposed as a topical agent that may accelerate wound healing and have antibacterial and analgesic properties. One hundred fifteen patients with partial-thickness burns were randomly assigned to conventional (n = 58) or MEBO treatment (n = 57). A verbal numerical rating score of pain was made in the morning, after burn dressing, and some 8 hours later. Patient pain profiles were summarized by locally weighted regression smoothing technique curves and the difference between treatments estimated using multilevel regression techniques. Mean verbal numerical rating scale pain levels (cm) in week 1 for all patients were highest at 3.2 for the after dressing assessment, lowest in the evening at 2.6, and intermediate in the morning at 3.0. This pattern continued at similar levels in week 2 and then declined by a mean of 0.5 in all groups in week 3. There was little evidence to suggest a difference in pain levels by treatment group with the exception of the postdressing pain levels in the first week when those receiving MEBO had a mean level of 0.7 cm (95% confidence interval, 0.2 to 1.1) lower than those on conventional therapy. MEBO appeared to bring greater pain relief for the postdressing assessment during the first week after burns. This initial relief, together with comparable pain levels experienced on other occasions, indicates that MEBO could be an alternative to conventional burns management.

摘要：<正> The article expounds the therapeutic features of the Moist Exposed Burn Therapy(MEBT)in the treatment of-burn injuries by means of experimental research data and clinical application experiences about MEBT and confirmsthat the principle and method of conventional dry therapy for burn injuries is contrary to burn pathogenesis,whileMEBT is an effective medical technique which is in conformity with burn pathogenesis at present.Histogical studies confirmed:microscopical examination of wound tissue treated with dry exposure therapyshowed that the granulation tissue was atrophic,in which the lobocytes exudated,collagenous fibers wereeosinophilous.An inanimate sign was emerged in the granulation tissue.The wound tissue treated with MEBT wasfull of vitality,fibroblasts proliferated actively and there were aboundant blood vessels.The comparison study be-tween amnion overlying therapy and MEBT in the treatment of superfcialⅢ°burnt wound confrmed that the latercould make the wound heal through epidermization.The