摘要：目的:观察深Ⅱ度烧伤患者应用湿润烧伤膏治疗后疗效。方法:将我院83例深Ⅱ度烧伤患者随机分组,对照组41例给予磺胺嘧啶银乳膏治疗,观察组42例联合湿润烧伤膏治疗,对比两组患者治疗后炎症因子水平、疼痛、愈合时间、瘢痕状态及水疱发生率。结果观察组治疗后肿瘤坏死因子-α(TumorNecrosisFactor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)、白细胞介素-10(interleukin-10,IL-10)水平、视觉模拟评分法(VisualAnalogueScale/Score,VAS)、温哥华瘢痕量表(VancouverScarScale,VSS)评分,创面愈合时间及水疱发生率均低于对照组(P<0.05)。结论:湿润烧伤膏能够有效促进深Ⅱ度烧伤患者创面愈合,抑制炎症反应,改善瘢痕形态,减轻疼痛。

摘要：目的:考察水飞蓟喷雾剂对大鼠深Ⅱ度烫伤组织病理学及血清白细胞介素-1（interleukin-1,IL-1）、肿瘤坏死因子-α（tumor necrosis factor,TNF-α）的影响。方法:建立深Ⅱ度烫伤模型大鼠,随机分成为模型组、美宝湿润烧伤膏组(24 g·kg-1)、水飞蓟小剂量组(24 g·kg-1)、水飞蓟中剂量组(48 g·kg-1)、水飞蓟大剂量组(96 g·kg-1)和空白组,连续给药21 d,分别在造模后3 d、7 d、14 d、21 d检测血清IL-1、TNF-α含量;HE染色检测烫伤创面病理学变化。结果:与模型组相比,烫伤后3 d、7 d、14 d、21 d,美宝湿润烧伤膏组和水飞蓟小、中、大剂量组血清TNF-α和IL-1均显著降低,其中水飞蓟大剂量组血清降低程度更大（P<0.05）。大鼠烫伤创面HE染色,水飞蓟喷雾剂可明显减轻表皮层、真皮层水肿,促进新生细胞增殖和皮肤组织修复。结论:水飞蓟喷雾剂对大鼠深Ⅱ度烫伤创面有修复作用,可促进烫伤创面的愈合,可能与降低血清IL-1和TNF-α抗炎作用有关。

摘要：目的：探讨两种不同敷料联合自体微粒皮种植术对深Ⅱ度烧伤的疗效。方法：选取2018年9月-2020年10月在笔者医院就诊的90例深Ⅱ度烧伤患者，按随机数表法分为对照组和试验组，各45例。对照组给予湿润烧伤膏联合自体微粒皮种植术进行治疗；试验组给予水凝胶敷料联合自体微粒皮种植术进行治疗。比较两组患者疗效、创面愈合情况、温哥华瘢痕量表（Vancouverscarscale,VSS）评分、血清致痛因子水平及不良反应。结果：治疗3周后，两组患者总有效率比较差异无统计学意义（P>0.05）；试验组患者创面上皮形成时间、创面愈合时间及不良反应发生率数值均低于对照组（P<0.05）；治疗3周后，两组血清前列腺素E2（Prostaglandin,PGE2）、神经肽（NeuropetideY,NPY）、5-羟色胺（5-Hydroxytryptamine,5-HT）水平均降低，且试验组低于对照组（P<0.05）。治疗2个月后，试验组VSS评分低于对照组（P<0.05）。结论：与湿润烧伤膏联合自体微粒皮种植术治疗深Ⅱ度烧伤效果相比，水凝胶敷料联合自体微粒皮种植术治疗深Ⅱ度烧伤可提升创面愈合速度，降低血清致痛因子水平，减少瘢痕形成，且不良反应较少，值得临床应用。

摘要：Background and Aim: Natural topical products have been used to enhance wound healing, especially in immunocompromised animals. The aims of this study were to evaluate and to compare the effects of moist exposed burn ointment (MEBO) and honey on the healing of full-thickness skin wounds in immunocompromised dogs. Materials and Methods: The study was conducted using 12 adults, apparently healthy mongrel dogs. Immunosuppression was induced in six dogs by oral administration of prednisone (2 mg/kg) and azathioprine (2 mg/kg), once a day for 21 days. On each dog, a total of 9, 1.5 cm in diameter full-thickness skin circular wounds were created aseptically in the thoracolumbar area under general anesthesia using customized skin punch biopsy kit. In a random fashion, three wounds in each dog were treatment using MEBO (contains b-sitosterol, baicalin, and berberine as active ingredients in a base of beeswax and sesame oil), honey or no treatment (control), once per day for 21 days. Wounds were grossly evaluated once a day for signs of inflammation or infection. In addition, biopsy specimens and digital imaging data of each wound were obtained on days 7, 14, and 21 for histopathological evaluation of the healing process. Results: Wounds in immunocompromised dogs appeared to heal significantly in a slower fashion than in non-immunocompromised counterparts. Digital analysis data showed that MEBO-treated wounds expressed better epithelialization area, faster contraction, and smaller wound area percentage when compared with honey-treated wounds. Histopathological analysis showed significantly higher angiogenesis scores in MEBO-treated wounds when compared with other treatments. Conclusion: Results of this study showed that MEBO resulted in significant enhancement of wound healing in both healthy and immunocompromised dogs. However, when compared to honey, the wound healing effect of MEBO was superior to that of honey.